Two big studies came out last week, one from the good folks at Yale and the other from equally as noble folks at Columbia, in partnership with the Children’s Hospital of Boston.
Both studies took a look at the importance of infancy on obesity in adults. As I have mentioned, and as I am sure you know, the obesity epidemic continues to climb, with the new numbers released last week showing that over 30% of the residents in nine states are obesity– much higher figures than just ten years ago. Doctors, scientists and fitness gurus are all trying to figure out what can be done to stem the tide of unhealthy weight gain.
According to the Yale University study, an individual’s weight is set in the brain before birth. In other words, our size is being wired into our brains in utero. For many people, portions of the brain that would trigger satiety are just not firing properly, causing those individuals to eat more.
“It appears that this base wiring of the brain is a determinant of one’s vulnerability to develop obesity,” said Tamas Horvath, chair and professor of comparative medicine and professor of neurobiology and obstetrics & gynecology at Yale School of Medicine, who is also co-director of the Yale Program in Integrative Cell Signaling and Neurobiology of Metabolism. “These observations add to the argument that it is less about personal will that makes a difference in becoming obese, and, it is more related to the connections that emerge in our brain during development.”
Horvath also mentions that this cerebral wiring leads to other problems. “Those who are vulnerable to diet-induced obesity also develop a brain inflammation, while those who are resistant, do not,” he said. “This emerging inflammatory response in the brain may also explain why those who once developed obesity have a harder time losing weight.”
Meanwhile, over at Columbia, researchers studying births over a period of 14 years (and over a half a million births) found that babies who were heavier at birth were much more likely to become obese adults. The researchers worked with the premise that a healthy weight increase while pregnant was about 18-22 pounds. As the expectant mothers would put on more weight, so too grew the chances that the baby would be large, with the likelihood one and a half times with a gain of 40 pounds and more than doubled with a gain of 52 pounds.
“These are the most important nine months of life from the standpoint of development,” said Dr. David Ludwig of Children’s Hospital Boston. “Our cells, tissues, even brain structures are being formed and fine-tuned so that having too high blood sugar and other abnormal metabolic influences can affect that infant not just at the moment but potentially throughout life.
“For an adult to gain an extra 10 pounds and then maybe lose it doesn’t cause permanent changes in that individual’s biology,” Ludwig said. “But, for a fetus to gain too much weight during key [moments] may permanently alter the brain circuits that affect appetite and metabolism, fat tissues or other parts of the body that have a permanent role in body weight regulation.”